Sequencing Challenging FFPE Cancer Samples to Identify Cancer Driver Genes and Novel Biomarkers
نویسنده
چکیده
Biopsies or tissue samples from cancer patients are routinely stored in formalin-fixed, paraffin-embedded (FFPE) tissue blocks. Sequencing these samples has proved challenging, because the process partially degrades and limits the amount of genomic material. Advanced approaches, such as nextgeneration sequencing (NGS), generate high-quality genomic data and are suitable for analyzing these valuable samples. Yet, some sequencing preparation methods further degrade the already low-quality FFPE sample DNA.
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